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NEUROSONOLOGY AND CEREBRAL HEMODYNAMICS
Official Journal of the Bulgarian Society of Neurosonology and Cerebral Hemodynamics
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fMRI
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1.
NEUROSONOLOGY AND CEREBRAL HEMODYNAMICS, vol. 4, 2008, No. 2
,
,
,
Въвеждането в последните десетилетия на невроизобразяващи (neuroimaging) методи като позитрон емисионната томография (PET) и функционалното магнитно резонансно изобразяване (
fMRI
) позволиха да се проследи регионалната активност на групи от неврони при изпълняване на различни когнитивни задачи от здрави нормални индивиди.
Въвеждането в последните десетилетия на невроизобразяващи (neuroimaging) методи като позитрон емисионната томография (PET) и функционалното магнитно резонансно изобразяване (fMRI) позволиха да се проследи регионалната активност на групи от неврони при изпълняване на различни когнитивни задачи от здрави нормални индивиди.
Оказа се, че от една страна, някои когнитивни операции като перцепцията на чувана и прочетена вербална информация, активират съвсем различни и локално-ограничени невронни структури, а от друга страна, редица дейности, като напр. мисленето относно значението на дадена дума, активират обширни корови области на лявата хемисфера едновременно във фронталния темпоралния и париеталния дял.
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2.
NEUROSONOLOGY AND CEREBRAL HEMODYNAMICS, vol. 4, 2008, No. 2
,
,
,
Дразненето на определено място води до промени на дистални области, функционално свързани с него, което беше доказано с
fMRI
и PET, съчетани с рТМС [37].
Мястото на приложение зависи от целта на стимулацията. Ако търсим повлияване на епилептогенно огнище, това ще бъде самото огнище, установено по клинични, невроизобразяващи или неврофизиологични методики.
Дразненето на определено място води до промени на дистални области, функционално свързани с него, което беше доказано с fMRI и PET, съчетани с рТМС [37].
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Unilateral left prefrontal TMS produces intensity-dependant bilateral effects as measured by interleaved BOLD
fMRI
.
Nahas Z, Lomarev M, Roberts D et al.
Unilateral left prefrontal TMS produces intensity-dependant bilateral effects as measured by interleaved BOLD fMRI.
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3.
NEUROSONOLOGY AND CEREBRAL HEMODYNAMICS, vol. 7, 2011, No. 1
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,
,
Single photon emission tomography (SPECT), positron emission tomography (PET), functional magnetic resonance imaging (
fMRI
), ultrasound neuroimaging and functional transcranial Doppler ultrasound are among the well established and widely applied FNM.
Single photon emission tomography (SPECT), positron emission tomography (PET), functional magnetic resonance imaging (fMRI), ultrasound neuroimaging and functional transcranial Doppler ultrasound are among the well established and widely applied FNM.
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Many questions concerning the dynamics of language processes in aphasia have been answered thanks to the intensive use of
fMRI
in studies of brain reorganization developed for Bulgaria to the impaired language functioning.
Many questions concerning the dynamics of language processes in aphasia have been answered thanks to the intensive use of fMRI in studies of brain reorganization developed for Bulgaria to the impaired language functioning.
When lesions are small, recovery is usually good and supported by mechanisms of the left hemisphere. When much language eloquent cortex is damaged, structures of the right hemisphere take part in the recovery [16].
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Neural correlates of access to specific verbal information have been determined through event-related
fMRI
demonstrating significant differences in the activation from visually provided words and similar “non-words” [7].
Neural correlates of access to specific verbal information have been determined through event-related fMRI demonstrating significant differences in the activation from visually provided words and similar “non-words” [7].
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This approach is effective for studying the neural basis of speech production and the effects of speech and language disorders by
fMRI
[37].
The potential for assessment of the neural mechanisms of motor speech control, motor speech disturbances, and motor speech development is increasing along with the perfection of contemporary neuroimaging techniques. Applying pauses or silent intervals in volume acquisition or block design, a pronounced activation can be obtained without complementary movements which could mask the activation of sought signals.
This approach is effective for studying the neural basis of speech production and the effects of speech and language disorders by fMRI [37].
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Assessment of the hemispheric dominance of language before carotid endarterectomy is another important application of
fMRI
[73].
Assessment of the hemispheric dominance of language before carotid endarterectomy is another important application of fMRI [73].
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The efficacy of
fMRI
follow-up of neuronal activity changes in continuous speech rehabilitation has been shown [31, 55].
The efficacy of fMRI follow-up of neuronal activity changes in continuous speech rehabilitation has been shown [31, 55].
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fMRI
is a renowned non-invasive technique for preoperative mapping of language areas.
Neuro-oncological practice is not only a motivator out also a recipient of the attainments of language function assessment through FNM.
fMRI is a renowned non-invasive technique for preoperative mapping of language areas.
The possibility of precise localization of brain areas responsible for language functions is especially important when a precise identification of the neoplasm site is needed or when it affects strategic language areas and treatment should be extremely conservative. Two paradigms have been tested for estimation of speech lateralization and for visualization of cortical areas: naming a verb, appropriate to a given noun, and generation of words containing a given letter. These conditions provide results visualizing frontal and temporal speech areas, determining the dominant hemisphere [4, 27,
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Preoperative
fMRI
is optimal for localizing specific brain functions controlling the motor, sensory and language spheres [48].
Preoperative fMRI is optimal for localizing specific brain functions controlling the motor, sensory and language spheres [48].
Such assessment of language areas and functions alone, without direct brain mapping is though not recommended if important surgical decisions are to be made [67, 76].
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Like other neuroimaging methods, sensitive to perfusion, such as PET and
fMRI
, fTDU is based on the close relationship between changes of cerebral blood flow and neuronal activity.
Functional transcranial Doppler ultrasound (fTDU) with application of different tests is a complementary neuroimaging tool evaluating changes of blood perfusion caused by neuronal activation during cognitive assessment.
Like other neuroimaging methods, sensitive to perfusion, such as PET and fMRI, fTDU is based on the close relationship between changes of cerebral blood flow and neuronal activity.
This method assures much better temporal resolution compared to other neuroimaging techniques. Other advantages include low dependence on motion artifacts, easy application even in children and in uncooperative patients, and noninvasiveness. As an event-related neuroimaging method monitoring blood flow changes in middle cerebral arteries it has been applied for determining the brain lateralization of language and other cognitive functions. A significant increase in velocity has been registered in the dominant hemisphere during a cognitive task [8, 42]. At the same time, fTDU spectroscopy assures a more understandable picture of changes related to the influence of a given mental stimulus [25, 52].
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A
fMRI
and TCD study.
Altamura C, Reinhard M, Vry MS, Kaller CP, Hamzei F, Vernieri F, Rossini PM, Hetzel A, Weiller C, Saur D. The longitudinal changes of BOLD response and cerebral hemodynamics from acute to subacute stroke.
A fMRI and TCD study.
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fMRI
characterization of the language formulation area.
Dien J, Franklin MS, Michelson CA, Lemen LC, Adams CL, Kiehl KA.
fMRI characterization of the language formulation area.
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Imaging speech production using
fMRI
.
Gracco VL, Tremblay P, Pike B.
Imaging speech production using fMRI.
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Kozub J, Urbanik A, Chrzan R, Karcz P [Presurgical functional brain examination MR (
fMRI
)].
Kozub J, Urbanik A, Chrzan R, Karcz P [Presurgical functional brain examination MR (fMRI)].
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Single-trial
fMRI
shows contralesional activity linked to overt naming errors in chronic aphasic patients.
Postman-Caucheteux WA, Birn RM, Pursley RH, Butman JA, Solomon JM, Picchioni D, McArdle J, Braun AR.
Single-trial fMRI shows contralesional activity linked to overt naming errors in chronic aphasic patients.
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4.
NEUROSONOLOGY AND CEREBRAL HEMODYNAMICS, vol. 9, 2013, No. 2
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,
,
In the brain, such ultrasensitive Doppler paves the way for fUltrasound (functional ultrasound imaging) of brain activity with unprecedented spatial and temporal resolution compared to
fMRI
.
precision characterization of complex vascular and cardiac flows. It also gives ultrasound the ability to detect very subtle blood flow in very small vessels.
In the brain, such ultrasensitive Doppler paves the way for fUltrasound (functional ultrasound imaging) of brain activity with unprecedented spatial and temporal resolution compared to fMRI.
Examples such as the functional imaging of cerebral blood volume during epileptic seizures will be presented and ill emphasize the potential of this new imaging modality.
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5.
NEUROSONOLOGY AND CEREBRAL HEMODYNAMICS, vol. 10, 2014, No. 1
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,
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Recent examinations via functional Magnetic Resonance Imaging (
fMRI
) of the brain try to explain their pathogenesis but it still remains insufficient [4].
The hallucinations vary from simple (photopsias, scotoms, simple colored objects), to more complex (different pictures, faces) [6]. The causes of their occurrence are numerous from different psychoses, deliria, dementias to conditions with unknown etiology as the Charles-Bonnet Syndrome [2, 5, 13].
Recent examinations via functional Magnetic Resonance Imaging (fMRI) of the brain try to explain their pathogenesis but it still remains insufficient [4].
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6.
NEUROSONOLOGY AND CEREBRAL HEMODYNAMICS, vol. 13, 2017, No. 2
,
,
,
fMRI
studies have shown reorganization of motor and auditory cortex in professional musicians and other studies showed the changes in neurotransmitter and hormone serum levels in correlation to music.
Due to mechanism of neuroplasticity, brain is capable of making new connections, activating new pathways and unmasking secondary roads. Music is a strong stimulus for neuroplasticity, thus having possibility to enhance recovery after stroke.
fMRI studies have shown reorganization of motor and auditory cortex in professional musicians and other studies showed the changes in neurotransmitter and hormone serum levels in correlation to music.
Results of numerous studies showed that listening to music can improve cognition, motor skills and moods, enhancing recovery after brain injury. In the field of visual art, brain lesion can lead to the visuospatial neglect, loss of details and significant impairment of artistic work while the lesions affecting the left hemisphere reveal new artistic dimensions, disinhibit the right hemisphere, work is more spontaneous and emotional with the gain of artistic quality. All kinds of arts (music, painting, dancing...) stimulate the brain. They should be part of the treatment processes. Work of many artists is an excellent example for the interweaving the neurology and arts.
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fMRI
studies have shown reorganization of motor and auditory cortex in professional musicians.
Using modern technology in science, as was already pointed out, allows an almost direct insight into the changes that music makes in human brain. Music stimulates specific regions of the brain and affects processes responsible for memory, motor control, timing and language.
fMRI studies have shown reorganization of motor and auditory cortex in professional musicians.
There are other studies that analyze the changes in neurotransmitter and hormone serum levels in correlation to music. Based on experience and on results of numerous studies, it is easier to understand that music is biologically and not just aesthetically, a part of human life [4, 1].
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A
fMRI
study showed that watching of dance movement stimulates activation of motor and other brain areas of all after-stroke patients, but in larger extent in patients with dancing experience (ballet or capoeira dancers).
brain was becoming larger with practice and on the fifth day in both groups the activation was similar [17].
A fMRI study showed that watching of dance movement stimulates activation of motor and other brain areas of all after-stroke patients, but in larger extent in patients with dancing experience (ballet or capoeira dancers).
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7.
NEUROSONOLOGY AND CEREBRAL HEMODYNAMICS, vol. 14, 2018, No. 1
,
,
,
Neuroimaging methods: functional magnetic resonance imaging (
fMRI
), positron emission tomography (PET) and single-photon emission computed tomography (SPECT).
Neuroimaging methods: functional magnetic resonance imaging (fMRI), positron emission tomography (PET) and single-photon emission computed tomography (SPECT).
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fMRI
data demonstrating decreased mirror neuron activity while observing people expressing different emotions e.g.
fMRI data demonstrating decreased mirror neuron activity while observing people expressing different emotions e.g.
anger, joy, surprise [8];
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Molenberghs P, Cunnington R, Mattingley J.Brain regions with mirror properties: A meta-analysis of 125 human
fMRI
studies.
Molenberghs P, Cunnington R, Mattingley J.Brain regions with mirror properties: A meta-analysis of 125 human fMRI studies.
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8.
NEUROSONOLOGY AND CEREBRAL HEMODYNAMICS, vol. 14, 2018, No. 2
,
,
,
fMRI
studies have shown reorganization of a motor and auditory cortex in professional musicians and other studies showed the changes in neurotransmitter and hormone serum levels in correlation to music.
The restorative window for stroke recovery is much longer than previously thought. The optimal time for brain repair appears to be at later stage of stroke rather than the earlier stage. It is expected that these new insights will advance our understanding of stroke recovery and assist in developing the next generation of restorative approaches with enhancing and harnessing neuroplasticity by multiple actions: enhancing the mirror neuron system for chronic stroke recovery, using different pharmaceutical interventions for activating growth factors and neurotrophins in rewiring neurovascular network. Due to a mechanism of neuroplasticity, the brain is capable of making new connections, activating new pathways and unmasking secondary roads. Music is a strong stimulus for neuroplasticity, thus having a possibility to enhance recovery after stroke.
fMRI studies have shown reorganization of a motor and auditory cortex in professional musicians and other studies showed the changes in neurotransmitter and hormone serum levels in correlation to music.
Results of numerous studies showed that listening to music can improve cognition, motor skills and moods, enhancing recovery after brain injury. In the field of visual art, the brain lesion can lead to the visuospatial neglect, loss of details and significant impairment of artistic work, while activation of neuroplasticity restores the skill and function again. All kinds of arts (music, painting, dancing...) stimulate the brain. They should be the part of treatment processes.
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Музиката стимулира активно невропластичността и подобрява възстановяването след МИ – с
fMRI
се установява реорганизация на моторната и слуховата кора при професионални музиканти, откриват се промени в серумните нива на невротрансмитери и хормони в зависимост от музиката.
Възстановителният период след МИ е по-дълъг, отколкото се предполагаше. Оптималното време за реорганизация на мозъка изгрежса е в по-късните стадии, а не в началния етап. Очаква се тези нови схващания да подобрят разбирането ни за възстановяването след МИ и да подпомогнат разработването на нови възстановителни подходи, повишаващи невропластичността: подобряване на огледалната невронна система при хроничен МИ, използване на различна фармакотерапия за активиране на растежни фактори и невротрофини при възстановяване на невроваскуларната мрежа и др. При наличие на невропластичност, мозъкът е в състояние да създава нови връзки, да активира нови пътища и да включва вторични вериги.
Музиката стимулира активно невропластичността и подобрява възстановяването след МИ – с fMRI се установява реорганизация на моторната и слуховата кора при професионални музиканти, откриват се промени в серумните нива на невротрансмитери и хормони в зависимост от музиката.
Слушането на музика може да подобри познавателните способности, двигателните умения, настроението и възстановяването след мозъчно увреждане. Мозъчните увреждания могат да доведат до визуално-пространствен неглект и значително увреждане на артистичността. Активирането на невропластичността чрез визуални изкуства възстановява отново уменията и функцията. Всички видове изкуства (музика, живопис, танци...) стимулират мозъка. Те трябва да са част от лечебния процес.
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To evaluate activation patterns of verbal fluency with functional magnetic resonance imaging (
fMRI
) in patients with relapsing-remitting multiple sclerosis (RRMS) and healthy controls.
To evaluate activation patterns of verbal fluency with functional magnetic resonance imaging (fMRI) in patients with relapsing-remitting multiple sclerosis (RRMS) and healthy controls.
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All subjects were evaluated by the Isaac’s test and underwent
fMRI
scanning during a Word Generation test.
Twenty-four patients with RRMS and 14 healthy controls, all matched by age, sex and education were included in this study. The mean duration of the disease was 8.54±0.69 years with mean EDSS score 1.83±0.64.
All subjects were evaluated by the Isaac’s test and underwent fMRI scanning during a Word Generation test.
All fMRI data were analyzed with SPM for MATLAB 2017.
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All
fMRI
data were analyzed with SPM for MATLAB 2017.
Twenty-four patients with RRMS and 14 healthy controls, all matched by age, sex and education were included in this study. The mean duration of the disease was 8.54±0.69 years with mean EDSS score 1.83±0.64. All subjects were evaluated by the Isaac’s test and underwent fMRI scanning during a Word Generation test.
All fMRI data were analyzed with SPM for MATLAB 2017.
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fMRI
, multiple sclerosis, verbal fluency
fMRI, multiple sclerosis, verbal fluency
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